Table 2

 Methodology of reports of original research

MethodologyNo of articles per 100 000 MEDLINE publicationsPercentage change (95% CI)†p value†
Before IOM reportAfter IOM report
†p values and 95% confidence intervals were calculated from a Poisson comparison of publication rates before and after publication of the IOM report.
Qualitative studies1.13.0+272% (+72% to +431%)<0.001
Case reports/case series13.314.9+12% (−4% to +30%)0.144
Correlational studies0.50.8+56% (−25% to +326%)0.235
Cross-sectional surveys3.09.7+326% (+248 to +427%)<0.001
Case-control studies1.93.3+72% (+19% to +249%)0.004
Cohort studies2.32.6+15% (−20% to +66%)0.451
Intervention studies1.24.0+344% (+224% to +528%)<0.001
Systematic reviews0.31.5+558% (+237% to +1319%)<0.001
Decision analyses0.31.0+358% (+147% to +873%)0.005